Tissue-repair research
In vitro and animal models of wound healing, tendon, ligament and skeletal-muscle repair.
Peptide · Research use only
BPC-157
A synthetic 15-amino-acid peptide, supplied as lyophilised powder with HPLC purity, mass confirmation and net peptide content — for laboratory research use only.
Also known as BPC 157 · PL 14736 · Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Overview
What BPC-157 is
BPC-157 is a synthetic pentadecapeptide whose sequence — Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val — corresponds to a fragment found in human gastric juice. It appears throughout the research literature on tissue repair, angiogenesis and gastrointestinal models.
For a peptide, purity is only half the specification. The other half is net peptide content: how much of the weighed powder is peptide rather than counter-ion, water and residual solvent. A lyophilised peptide at 98% HPLC purity can be 80% peptide by mass, and that gap changes every calculation a laboratory makes from the vial.
Eastling supplies BPC-157 as a white lyophilised powder, ≥98% by HPLC, identity confirmed by mass spectrometry, with acetate as the counter-ion unless another form is agreed. This material is supplied for laboratory research and further manufacturing use only — it is not a medicine, food or cosmetic ingredient, and it is not for human or animal consumption.
- ≥ 98% by HPLC, chromatogram and integration method per batch
- Identity confirmed by ESI-MS against theoretical mass 1419.53
- Net peptide content and counter-ion stated on the COA
- Lyophilised in amber vials, shipped with desiccant
Identity
The record.
The identifiers your specification sheet, customs paperwork and product label all have to agree on. Where a number depends on the salt form, both are given.
- Chemical name
- Pentadecapeptide BPC-157
- Sequence
- GEPPPGKPADDAGLV (15 aa, linear)
- CAS number
- 137525-51-0
- Molecular formula
- C₆₂H₉₈N₁₆O₂₂
- Molecular weight
- 1419.53 g/mol (free peptide)
- Appearance
- White lyophilised powder
- Solubility
- Freely soluble in water and aqueous buffer
- Counter-ion
- Acetate (standard); TFA-free grades on request
- HS code
- 2937.19 — indicative, confirm with your customs broker
- Storage
- −20 °C, sealed, protected from light
HS codes are indicative only. Final classification is confirmed per shipment with your customs broker.
Manufacture
How it is made.
Solid-phase synthesis, then two purification decisions that determine what the COA actually tells you.
- 01
Solid-phase synthesis
The 15 residues are assembled on resin, with the difficult Pro-Pro-Pro stretch driving coupling strategy and, ultimately, the deletion-sequence impurity profile.
- 02
Cleavage and deprotection
The peptide is cleaved from resin and side-chain protecting groups removed; this step determines whether TFA ends up in the final material.
- 03
HPLC purification
Preparative reverse-phase purification isolates the full-length peptide from deletion and truncation sequences — the impurities that a single purity figure can obscure.
- 04
Counter-ion exchange and lyophilisation
Acetate exchange followed by lyophilisation to a low-water, free-flowing cake, then HPLC, MS and water testing before release.
Applications
Where it is used.
Supplied to laboratories working in these areas. We do not provide dosing, reconstitution protocols for administration, or clinical guidance.
Gastrointestinal models
Studied in gastric and intestinal protection research, the area its sequence origin points to.
Angiogenesis research
Assays looking at vessel formation and endothelial cell behaviour.
Specification
Release criteria.
The written limits we release against, with the method used to test each one. Batch results for the lot you receive are stated on its certificate of analysis.
| Parameter | Limit | Method |
|---|---|---|
| Appearance | White lyophilised powder or cake | Visual |
| Purity | ≥ 98.0% | RP-HPLC-UV, 214 nm |
| Identity | Matches theoretical mass 1419.53 ± 0.5 | ESI-MS |
| Net peptide content | ≥ 80% (stated per batch) | Amino-acid analysis / UV |
| Counter-ion | Acetate; TFA content ≤ 1.0% where applicable | Ion chromatography |
| Water content | ≤ 6.0% | Karl Fischer |
| Related substances | Largest single impurity ≤ 1.0% | RP-HPLC |
| Heavy metals | ≤ 10 ppm | ICP-MS |
| Total plate count | ≤ 100 cfu/g | Plate count |
| Endotoxin | Tested on request | LAL |
| Shelf life | 24 months at −20 °C, unopened | Stability programme |
Tighter limits — for example a lower heavy-metal ceiling or a residual-solvent panel — can be quoted against your own specification wording.
Certificate
Reading the certificate.
Peptide COAs are easy to make look good. These three figures are where honest ones differ from decorative ones.
Purity versus net peptide content
HPLC purity is the main peak as a share of all UV-absorbing material. Net peptide content is how much actual peptide is in the vial. At 98% purity with 82% net content, a 5 mg vial holds about 4.1 mg of peptide — and every assay calculation should use that number.
Which impurities are being counted
Deletion sequences elute close to the main peak. Ask whether the impurity profile lists individual sequences or only a total. A “total ≤2%” line can hide a single 1.9% deletion impurity.
The counter-ion is part of the product
TFA is the default in many syntheses and it is not inert in cell work. Acetate is the safer default for research use; if your protocol is sensitive to residual TFA, state the limit and have it tested.
Documentation & packaging
What ships with it.
The paperwork travels with the goods. If your QA team needs an extra declaration, ask before the order is released — some are issued per production lot and cannot be retrofitted.
Certificate of analysis
Purity, identity by MS, net peptide content, water, counter-ion and microbiological results, one lot per page.
Analytical data
Full HPLC chromatogram with the gradient and wavelength stated, plus the ESI-MS spectrum.
SDS & specification
Safety data sheet for laboratory handling, and the written specification used for release.
Research-use statement
A signed statement that the material is supplied for laboratory research and further manufacturing use only, not for human or animal consumption.
| Pack size | Presentation | Typical use |
|---|---|---|
| 100 mg | Amber vial, 2 mL | Evaluation — quoted on request |
| 500 mg | Amber vial, 5 mL | Pilot scale |
| 1 g | Amber vial, 10 mL | Standard catalogue pack |
| 5 g+ | Amber vial or foil | Bulk — quoted per order |
Questions
Before you order.
The questions buyers actually ask about BPC-157. Anything not covered here, ask directly — you will get an answer from someone technical, not a template.
What does “research use only” actually mean?
It means the material is sold for laboratory research and further manufacturing use — not as a medicine, a food, a supplement or a cosmetic, and not for human or animal consumption. We do not supply dosing information, administration guidance or medical advice, and we do not sell to consumers.
What is net peptide content and why does it matter?
It is the mass of peptide in the vial as a percentage of the total powder, after accounting for water, counter-ion and residual solvent. It is the number a laboratory should use when preparing a solution of known concentration. We state it on the COA; many suppliers do not measure it at all.
Acetate or TFA salt?
Acetate is our standard, because residual TFA can interfere with cell-based work. If you need a TFA-free grade or a specific counter-ion, specify it before the order — it is a purification decision, not a labelling one.
Why is the specification ≥98% and not ≥99%?
Because a 15-residue peptide with a polyproline stretch makes 99% a much more expensive proposition, and most research protocols do not need it. If your work needs ≥99% with a defined impurity profile, that can be quoted as a custom specification — with a matching lead time.
How is it shipped?
Lyophilised powder ships at ambient temperature, which is adequate for the dry cake over normal transit times; cold-chain is available if your protocol or your customs route requires it. On arrival, store at −20 °C, sealed, protected from light.
Can you supply a different fill weight or a custom sequence?
Fill weights from 100 mg are quotable. Custom sequences and modifications are a separate project — send the sequence, the purity target and the quantity, and we will come back with feasibility rather than a price.
Do you test for endotoxin?
On request, by LAL. It is not part of the standard release specification because most research customers do not require it — but for cell-based work it is often the more relevant number than HPLC purity.
Is this the same as the “BPC-157” sold in capsules online?
No. Capsules sold direct to consumers are a different product category with different regulatory obligations, and we do not supply that market. This is the lyophilised research-grade peptide, sold to laboratories and manufacturers.
Related
Often quoted together.
Quotation
Ask for BPC-157, by the gram.
Send the quantity, the grade you need and the destination. You will get a written quotation with lead time, packaging options and the documentation set for this material.